That's the claim most longevity marketing overstates, and correcting it directly is the point of this page. NMN and NR are OTC supplements now cleared of regulatory ambiguity; sermorelin is a compounded, prescription-only peptide with a meaningfully thinner evidence base. We compare them separately: they're different purchase decisions, and forcing them into one ranking would hide that.
Over-the-counter, no prescription needed. NMN became unambiguously legal on September 29, 2025 when the FDA reversed its 2022 exclusion; NR has been a lawful supplement since 2016. Purity and third-party testing are the real differentiators here, not a 10-point evidence score, since these are OTC products, not prescriptions with clinical oversight to evaluate.
| Brand | Product | Price | Purity / testing |
|---|---|---|---|
| Tru Niagen | NR (patented Niagen) | ~$99/120ct | ChromaDex-patented ingredient; the most human-RCT-studied NR ingredient of any brand on this list |
| Renue By Science | NMN | ~$1.44/day (500mg) | Third-party HPLC-tested, published Certificates of Analysis, GMP facility |
| ProHealth Longevity | NMN (Uthever ingredient) | $27-$86 | Uses licensed, clinically-studied Uthever-brand raw NMN |
| Do Not Age | NMN & NR | ~$0.87/serving | Third-party lab tested, GMP & ISO9001-certified facilities |
| Thorne (ResveraCel) | NR blend (+ resveratrol, quercetin) | ~$60/30 servings | NSF Contents Certified: sitewide manufacturing trust signal |
| Tally Health | NAD+ blend (NMN-containing) | ~$50-59/mo | Testing/purity claims not independently confirmed: verify before buying |
| Wonderfeel | NMN (900mg) | $73-88/bottle | Testing/purity claims not independently confirmed: verify before buying |
Sermorelin is a different category entirely: a compounded, prescription-only peptide with no current Phase III trial data. Its only FDA approval was voluntarily withdrawn in 2008. All current use is off-label. We grade its evidence Limited-to-Moderate, distinctly below NMN/NR, and score clinics on the standard CitedRx rubric since this is a telehealth/prescription decision, not a supplement purchase.
Tiered LabCorp-based diagnostics ($350-$700) alongside sermorelin protocols, positioned as a data-driven optimization clinic.
Confirmed to require baseline IGF-1 and metabolic panel labs before prescribing, plus quarterly follow-up panels.
| Clinic | CitedRx Score | Labs required? | From |
|---|---|---|---|
| Marek Health | 6.2/10 | Yes | $250 intake |
| Hone Health | 6.2/10 | Yes | ~$150-250/mo |
| Genesis Lifestyle Medicine | 4.8/10 | Yes | $200-400/mo |
| Invigor Medical | 4.8/10 | Consultation-based | ~$285/mo |
Invigor Medical also offers an oral sermorelin option: oral peptide bioavailability is scientifically contested, so treat that specific formulation's efficacy claims with extra caution. See our research library for full evidence and citations.
NMN/NR supplement brands are not assigned a CitedRx Score: they're an OTC purchase decision, not a prescribing decision with clinical oversight to evaluate, so we compare them on purity, third-party testing, and price instead.
Sermorelin clinics use the standard CitedRx rubric, with one adjustment: because every sermorelin product is compounded and unapproved (there's no branded alternative to compare against, unlike GLP-1s), Evidence Match is capped low and uniform across all four clinics: differentiation instead comes from independent rating, pricing transparency, lab rigor, and regulatory standing.
Scores and comparisons are CitedRx's own composite, not a clinical endorsement. CitedRx may earn a referral fee if you sign up through a link on this page: see the disclosure in the footer.
No human trial has demonstrated that NMN or NR extends human lifespan. The ~20% median lifespan increase sometimes cited comes from a 2024 study in genetically premature-aging mouse models, not normal aging or humans. Human trials have shown NMN is safe and reliably raises blood NAD+ levels: that's a real, proven effect, just a different claim than lifespan extension.
Yes, as of September 29, 2025, when the FDA reversed its 2022 position that had excluded NMN from the dietary supplement definition, with confirming letters to individual suppliers issued in December 2025. NR (nicotinamide riboside) was never restricted and has been a lawful GRAS supplement since 2016.
No. NMN and NR are over-the-counter dietary supplements. Sermorelin is a compounded, prescription-only peptide with no current Phase III trial data: its only FDA approval (under the brand Geref) was voluntarily withdrawn in 2008. All current adult use is off-label and unapproved-compounded, a meaningfully thinner evidence base than NMN or NR.
It is not a controlled substance and is not on the FDA's restricted-compounding list, but as an unapproved compounded product it has not gone through FDA safety/effectiveness review the way an approved drug has. As of January 2026, FDA guidance requires compounders to document why an FDA-approved alternative (such as tesamorelin) isn't clinically appropriate before compounding sermorelin.
Human trials have tested doses up to 1,250 mg/day for 4-10 weeks without serious adverse events, reliably raising blood NAD+ levels. Most commercial products are dosed well below this ceiling.
CitedRx is an independent information resource and is not affiliated with the brands or clinics listed above. Pricing and testing claims are sourced from brand/provider sites and may change: confirm directly before purchasing. This page is for informational purposes only and is not medical advice; NMN and NR are dietary supplements not evaluated by the FDA for any specific health claim, and sermorelin is an unapproved compounded product: talk to a licensed clinician before starting any of these. CitedRx may earn a referral fee if you purchase or sign up through a link on this page; this does not affect comparisons or ranking order.